2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

Base Information

Chemical Name:2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate
CAS No.:262354-88-1
Molecular Formula:C₂₀H₂₂N₂O₆
Molecular Weight:386.404
Hs Code.:

Synonyms:2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

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Chemical Property of 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

Chemical Property:

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Technology Process of 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

There total 4 articles about 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 108-24-7
acetic anhydride

: 262354-85-8
2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl alcohol

: 262354-88-1
2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

Guidance literature:: With triethylamine; In dichloromethane; for 3h;
DOI:10.1016/S0040-4020(99)01015-7

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 262354-88-1
2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / K₂CO₃ / dimethylsulfoxide / 2 h / Heating

2: 0.68 g / NaBH₄ / methanol / 1 h / Heating

3: 81 percent / Et₃N / CH₂Cl₂ / 3 h

With sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1: Arylation / 2: Reduction / 3: Acetylation;
DOI:10.1016/S0040-4020(99)01015-7

Reference yield:

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 262354-88-1
2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)-5-nitrobenzyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / K₂CO₃ / dimethylsulfoxide / 2 h / Heating

2: 0.68 g / NaBH₄ / methanol / 1 h / Heating

3: 81 percent / Et₃N / CH₂Cl₂ / 3 h

With sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1: Arylation / 2: Reduction / 3: Acetylation;
DOI:10.1016/S0040-4020(99)01015-7