Technology Process of C21H16BrNO
There total 4 articles about C21H16BrNO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3BF4(1-)*C36H58BrN4(3+); (Ra)-4-hydroxy-2,6-bis(2,4,6-triisopropylphenyl)-9,14-bis(triisopropylsilyl)dinaphtho[1,3,2]dioxaphosphepine 4-oxide; sodium phosphate;
In
hexane; para-xylene;
at 20 ℃;
for 4h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja305795x
- Guidance literature:
-
With
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; C40H39N3O2;
In
methanol;
at -80 ℃;
for 6h;
Reagent/catalyst;
Overall yield = 93 percent; enantioselective reaction;
DOI:10.1021/acs.joc.9b02395
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium t-butanolate / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere
3.1: 3BF4(1-)*C36H58BrN4(3+); (Ra)-4-hydroxy-2,6-bis(2,4,6-triisopropylphenyl)-9,14-bis(triisopropylsilyl)dinaphtho[1,3,2]dioxaphosphepine 4-oxide; sodium phosphate / hexane; para-xylene / 4 h / 20 °C / Inert atmosphere
With
3BF4(1-)*C36H58BrN4(3+); (Ra)-4-hydroxy-2,6-bis(2,4,6-triisopropylphenyl)-9,14-bis(triisopropylsilyl)dinaphtho[1,3,2]dioxaphosphepine 4-oxide; triethylamine; sodium phosphate; sodium t-butanolate;
In
diethyl ether; hexane; dichloromethane; para-xylene;
1.2: Wittig reaction;
DOI:10.1021/ja305795x
