(2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate
• CAS No.: 1089146-57-5
• Molecular Formula: C₁₇H₂₄N₂O₅
• Molecular Weight: 336.388

Synonyms:(2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate

Chemical Property of (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate

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Technology Process of (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate

There total 1 articles about (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2S,4S)-methyl 4-azido-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)pyrrolidine-2-carboxylate (769970-73-2) → (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate (1089146-57-5)

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

DOI:10.1016/j.ejmech.2007.12.020

Reference yield: 53.0%

(2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate (1089146-57-5) + Cinnamoyl chloride (102-92-1,17082-09-6) → (2S,4S)-methyl 1-(3-(3,4-dimethoxyphenyl)propanoyl)-4-(cinnamamido)pyrrolidine-2-carboxylate (1089146-68-8)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/j.ejmech.2007.12.020

Reference yield: 39.0%

3-pyridinecarbonyl chloride (10400-19-8) + (2S,4S)-methyl 4-amino-1-((E)-3-(3,4-dimethoxyphenyl)propanoyl)pyrrolidine-2-carboxylate (1089146-57-5) → (2S,4S)-methyl 1-(3-(3,4-dimethoxyphenyl)propanoyl)-4-(nicotinamido)pyrrolidine-2-carboxylate (1089146-67-7)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/j.ejmech.2007.12.020

upstream raw materials:

(2S,4S)-methyl 4-azido-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)pyrrolidine-2-carboxylate

Downstream raw materials:

(2S,4S)-methyl 1-(3-(3,4-dimethoxyphenyl)propanoyl)-4-(nicotinamido)pyrrolidine-2-carboxylate

(2S,4S)-methyl 1-(3-(3,4-dimethoxyphenyl)propanoyl)-4-(cinnamamido)pyrrolidine-2-carboxylate

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