N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

Base Information

Chemical Name:N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester
CAS No.:392283-01-1
Molecular Formula:C₂₆H₃₈N₂O₅
Molecular Weight:458.598
Hs Code.:

Synonyms:N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

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Chemical Property of N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

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Technology Process of N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

There total 3 articles about N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134440-91-8
(2S,3S,8S,9S,4E,6E)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid methyl ester

: 392283-01-1
N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / 1 h

2: 25 mg / Et₃N / 1 h / 0 °C

3: 23 mg / aq. LiOH / tetrahydrofuran / 22 h

4: 73 percent / HATU; collidine / dimethylformamide / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; lithium hydroxide; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/es011182f

Reference yield:

: 329791-61-9
N-acetyl 4E,6E-3-amino-9-methyoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid methyl ester

: 392283-01-1
N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 23 mg / aq. LiOH / tetrahydrofuran / 22 h

2: 73 percent / HATU; collidine / dimethylformamide / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; lithium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/es011182f

Reference yield:

: N-Boc 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid methyl ester

: 392283-01-1
N-acetyl 4E,6E-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-alanyl methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 25 mg / Et₃N / 1 h / 0 °C

2: 23 mg / aq. LiOH / tetrahydrofuran / 22 h

3: 73 percent / HATU; collidine / dimethylformamide / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; lithium hydroxide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/es011182f