1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Base Information

Chemical Name:1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea
CAS No.:139693-28-0
Molecular Formula:C₃₄H₄₁N₃O₄S
Molecular Weight:587.783
Hs Code.:

Synonyms:1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

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Chemical Property of 1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

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Technology Process of 1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

There total 11 articles about 1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 139693-30-4
(3,5-di-tert-butyl)benzylamine

: 139693-27-9
4-(2-phthalimidoethoxy)-3-methoxybenzylisothiocyanate

: 139693-28-0
1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: With triethylamine; In ethyl acetate;
DOI:10.1021/jm960512h

Reference yield:

: 77387-57-6
3,5-bis(1,1-dimethylethyl)benzenemethanol

: 139693-28-0
1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: MnO₂ / CHCl₃ / 5 h / Heating

2: 87 percent / sodium acetate / methanol / Heating

3: 1.) 1 M borane - THF complex, 2.) 5 M aq. NaOH / 1.) THF, reflux, 24 h, 2.) MeOH, reflux, 2 h

4: 75 percent / Et₃N / ethyl acetate

With manganese(IV) oxide; sodium hydroxide; borane-THF; sodium acetate; triethylamine; In methanol; chloroform; ethyl acetate;
DOI:10.1021/jm960512h

Reference yield:

: 17610-00-3
3,5-Di-tert-butylbenzaldehyde

: 139693-28-0
1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / sodium acetate / methanol / Heating

2: 1.) 1 M borane - THF complex, 2.) 5 M aq. NaOH / 1.) THF, reflux, 24 h, 2.) MeOH, reflux, 2 h

3: 75 percent / Et₃N / ethyl acetate

With sodium hydroxide; borane-THF; sodium acetate; triethylamine; In methanol; ethyl acetate;
DOI:10.1021/jm960512h