139693-27-9

Upstream product

• 463-71-8 thiophosgene 
• 130972-90-6 tert-butyl N-[4-(2-bromoethoxy)-3-methoxybenzyl]carbamate 
• 130972-89-3 (4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester 
• 7149-10-2 vanillylamine hydrochloride 
• 130972-91-7 {4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-carbamic acid tert-butyl ester 

Downstream Products

• 184003-52-9 1-{4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-3-(4-trimethylsilanyl-benzyl)-thiourea 
• 139693-29-1 1-(4-tert-Butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea 
• 139693-28-0 1-(3,5-Di-tert-butyl-benzyl)-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea 
• 184003-47-2 1-{4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-3-(4-iodo-benzyl)-thiourea 

Relevant academic research and scientific papers

Analogues of capsaicin with agonist activity as novel analgesic agents: Structure-activity studies. 4. Potent, orally active analgesics

Structural features of three regions of the capsaicin molecule necessary for agonist properties were delineated by a previously reported modular approach. These in vitro agonist effects were shown to correlate with analgesic potency in rodent models. Comb

Novel N-benzyl-N1-phenyl and -phenalkyl-thioureas

Compounds of formula II wherein one of R1 and R2 is branched lower alkyl and the other is hydrogen or branched lower alkyl, R3 is hydrogen or C1 4alkyl, R4 and R5 are hydrogen, halogen, C1 5alkyl, substituted C1 5alkyl, aryl, substituted or unsubstituted aryl or a group of formula, -COOH, -COOR8 or -CONR9R10, wherein R8 is C1 5alkyl and R9 and R10 are, independently, hydrogen or C1 5alkyl, R6 and R7 have the meanings given for R4 and R5 or, together with the carbon atom to which they are attached, form a substituted or unsubstituted C3 7cyclo-alkyl group, R is -O-, -S- or -NH- and X is -(CH2)n- wherein n is zero, 1, 2 or 3, and their physiologically hydrolysable and acceptable esters and amides and pharmaceutically acceptable salts thereof, processes for their production and pharmaceutical compositions comprising them.