3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

Base Information

Chemical Name:3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester
CAS No.:107688-33-5
Molecular Formula:C₂₈H₃₂N₂O₇S
Molecular Weight:540.637
Hs Code.:

Synonyms:3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

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Chemical Property of 3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

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Technology Process of 3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

There total 13 articles about 3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107688-23-3
2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol

: 107688-33-5
3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

Guidance literature:: Multi-step reaction with 10 steps

1: anhydrous sodium carbonate / tetrahydrofuran / 16 h / 50 °C

2: 98 percent / pyridine / 1 h / 40 °C

3: 98 percent / tetra-n-butyl ammonium bromide, sodium iodide / toluene / 2 h / Heating

4: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

5: 77 percent / Amberlyst 15 / 120 h / 60 °C

6: acetic acid,H₂ / 10percent Pd/C / tetrahydrofuran / 25 h / 40 - 50 °C

7: sodium hydrogen carbonate sol., / CH₂Cl₂ / 15 h / Heating

8: 96 percent / triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

9: triethylamine, tert-butylhypochlorit sol. / CH₂Cl₂; CCl₄ / -50 - -40 °C

10: 30 percent Chromat_. / 1.) bortrifluoride-diethyl etherate; 4.)sodium carbonate sol. / 1.) - 40 deg C; 2.) r.t., 30 min; 3.) reflux, 2 h; 4.) 20 min

With pyridine; sodium hydroxide; Amberlyst 15; tert-butylhypochlorite; boron trifluoride diethyl etherate; tetrabutylammomium bromide; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; sodium carbonate; acetic acid; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

: 107688-26-6,116260-70-9,116260-74-3
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaurenitril

: 107688-33-5
3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

2: 77 percent / Amberlyst 15 / 120 h / 60 °C

3: acetic acid,H₂ / 10percent Pd/C / tetrahydrofuran / 25 h / 40 - 50 °C

4: sodium hydrogen carbonate sol., / CH₂Cl₂ / 15 h / Heating

5: 96 percent / triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

6: triethylamine, tert-butylhypochlorit sol. / CH₂Cl₂; CCl₄ / -50 - -40 °C

7: 30 percent Chromat_. / 1.) bortrifluoride-diethyl etherate; 4.)sodium carbonate sol. / 1.) - 40 deg C; 2.) r.t., 30 min; 3.) reflux, 2 h; 4.) 20 min

With sodium hydroxide; Amberlyst 15; tert-butylhypochlorite; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; sodium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

: 107688-27-7,116260-78-7,116262-35-2
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-7-carbonsaureamid

: 107688-33-5
3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,10-octahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / Amberlyst 15 / 120 h / 60 °C

2: acetic acid,H₂ / 10percent Pd/C / tetrahydrofuran / 25 h / 40 - 50 °C

3: sodium hydrogen carbonate sol., / CH₂Cl₂ / 15 h / Heating

4: 96 percent / triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

5: triethylamine, tert-butylhypochlorit sol. / CH₂Cl₂; CCl₄ / -50 - -40 °C

6: 30 percent Chromat_. / 1.) bortrifluoride-diethyl etherate; 4.)sodium carbonate sol. / 1.) - 40 deg C; 2.) r.t., 30 min; 3.) reflux, 2 h; 4.) 20 min

With Amberlyst 15; tert-butylhypochlorite; boron trifluoride diethyl etherate; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/S0040-4020(01)86863-0