N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide
CAS No.:1393751-19-3
Molecular Formula:C₂₆H₃₀N₂O₅S₂
Molecular Weight:514.667
Hs Code.:

Synonyms:N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Suppliers and Price of N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

There total 5 articles about N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1092547-35-7
(S)-N-allyl-N-(1-hydroxy-3-phenylpropan-2-yl)-4-methylbenzenesulfonamide

: 70-55-3
toluene-4-sulfonamide

: 1393751-19-3
N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: With copper(II) 2-ethylhexanoate; caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 24h; diastereoselective reaction;
DOI:10.1021/ol301984b

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1393751-19-3
N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; N-ethyl-N,N-diisopropylamine / acetone; water / 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 16 h / 20 °C

4.1: copper(II) 2-ethylhexanoate; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 130 °C

With lithium aluminium tetrahydride; copper(II) 2-ethylhexanoate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol301984b

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1393751-19-3
N-(((2S,5S)-5-benzyl-4-tosylmorpholin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; N-ethyl-N,N-diisopropylamine / acetone; water / 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 16 h / 20 °C

4.1: copper(II) 2-ethylhexanoate; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 130 °C

With lithium aluminium tetrahydride; copper(II) 2-ethylhexanoate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol301984b