3-Quinolinecarboxylicacid,4-methyl-(6CI)

Base Information

• Chemical Name: 3-Quinolinecarboxylicacid,4-methyl-(6CI)
• CAS No.: 103907-10-4
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.198
• Mol file: 103907-10-4.mol

Synonyms:3-Quinolinecarboxylicacid,4-methyl-(6CI)

Chemical Property of 3-Quinolinecarboxylicacid,4-methyl-(6CI)

Chemical Property:

• PSA: 50.19000
• LogP: 2.24140

Purity/Quality:

99%min ^*data from raw suppliers

4-Methylquinoline-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylicacid,4-methyl-(6CI)

There total 5 articles about 3-Quinolinecarboxylicacid,4-methyl-(6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl 4-methylquinoline-3-carboxylate (18936-34-0) → 4-methylquinoline-3-carboxylic acid (103907-10-4)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

2-aminoacetophenone (551-93-9) → 4-methylquinoline-3-carboxylic acid (103907-10-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 °C

2: H₂SO₄

3: aqueous NaOH; KMnO₄ / Erhitzen des Reaktionsprodukts mit Essigsaeure

With sodium hydroxide; potassium permanganate; sulfuric acid;

DOI:10.1021/jo01106a051

Reference yield:

9-methyl-3H-furo[3,4-b]quinolin-1-one (99970-03-3) → 4-methylquinoline-3-carboxylic acid (103907-10-4)

Guidance literature:

With sodium hydroxide; potassium permanganate; Erhitzen des Reaktionsprodukts mit Essigsaeure;

DOI:10.1021/jo01106a051

upstream raw materials:

4-methyl-3-quinolinecarbonitrile

9-methyl-3H-furo[3,4-b]quinolin-1-one

4-(2-acetyl-phenylimino)-dihydro-furan-2-one

2-aminoacetophenone

Refernces