cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

Base Information

Chemical Name:cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide
CAS No.:1378037-80-9
Molecular Formula:C₂₁H₁₄Cl₂N₈O
Molecular Weight:465.301
Hs Code.:

Synonyms:cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

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Chemical Property of cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

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Technology Process of cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

There total 7 articles about cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1378039-62-3
N-(6-aminopyrimidin-4-yl)cyclopropanecarboxamide

: 1378039-51-0
3,5-dichloro-4-(4-chloropyrazolo[4,3-c]pyridin-2-yl)benzonitrile

: 1378037-80-9
cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 0.5h; Sealed tube; Inert atmosphere; Microwave irradiation;

Reference yield:

: 114077-82-6
4-chloronicotinaldehyde

: 1378037-80-9
cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h

2: triethylamine; titanium tetrachloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: toluene / 1 h / 105 °C

4: dihydrogen peroxide / dichloromethane / 2 h / 20 °C

5: trichlorophosphate / 1 h / 85 °C

6: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With sodium azide; dihydrogen peroxide; titanium tetrachloride; caesium carbonate; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1378039-61-2
tert-butyl N-tert-butoxycarbonyl-N-(6-(cyclopropanecarboxamido)pyrimidin-4-yl)-carbamate

: 1378037-80-9
cyclopropanecarboxylic acid{6-[2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;