1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

Base Information

Chemical Name:1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene
CAS No.:1453814-04-4
Molecular Formula:C₂₀H₁₇NO₃
Molecular Weight:319.36
Hs Code.:

Synonyms:1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

Chemical Property:

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Technology Process of 1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

There total 5 articles about 1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1453814-03-3
2-methyl-4-(4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)but-3-yn-2-ol

: 1453814-04-4
1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

Guidance literature:: With potassium hydroxide; In toluene; at 110 ℃; for 16h; Darkness;
DOI:10.1016/j.tetlet.2013.07.144

Reference yield:

: 1453814-02-2
1-(((4-(4-bromophenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

: 1453814-04-4
1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

2: potassium hydroxide / toluene / 16 h / 110 °C / Darkness

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; toluene; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tetlet.2013.07.144

Reference yield:

: 76347-62-1
4-(3-hydroxy-3,3-dimethyl-1-propynyl)-1-bromobenzene

: 1453814-04-4
1-(((4-(4-ethynylphenyl)-2-methylbut-3-yn-2-yl)oxy)methyl)-2-nitrobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) bromide / nitromethane / 12 h / 20 °C / Darkness

2: triethylamine; copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

3: potassium hydroxide / toluene / 16 h / 110 °C / Darkness

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; potassium hydroxide; copper(ll) bromide; In tetrahydrofuran; nitromethane; toluene; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tetlet.2013.07.144