Technology Process of 1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-3-ol trifluoroacetate
There total 5 articles about 1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-3-ol trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 3-oxo-1-(phenylsulfonyl)-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
Heating / reflux;
With
sodium tetrahydroborate;
In
ethanol;
at 20 ℃;
for 0.75h;
trifluoroacetic acid;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 4-tert-Butylcatechol / xylene / 6 h / Heating / reflux
2.1: hydrogenchloride; zinc / methanol; water / 2 h / Heating / reflux
3.1: trichlorophosphate / 0.25 h / 20 °C
3.2: 1 h / 0 - 20 °C
4.1: dichloromethane / 20 °C
5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran; water / 20 °C
6.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 1 h / 20 °C
7.1: trifluoroacetic acid / dichloromethane / Heating / reflux
7.2: 0.75 h / 20 °C
With
hydrogenchloride; sodium hydroxide; 4-tert-Butylcatechol; tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; xylene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran; water / 20 °C
2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 1 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / Heating / reflux
3.2: 0.75 h / 20 °C
With
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane; water;