2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate
CAS No.:97486-33-4
Molecular Formula:C₃₅H₄₀N₄O₅SSi
Molecular Weight:656.878
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

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Chemical Property of 2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

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Technology Process of 2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

There total 3 articles about 2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79414-13-4
trimethylsilylethyl bromoacetate

: 97486-33-4
2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / K₂CO₃ / tetrahydrofuran; H₂O / Ambient temperature

2: 1.2N aq. HCl, H₂ / 10percent Pd/C / ethanol / 0.75 h

3: pyridine, phosphorus oxychloride / CH₂Cl₂ / 1 h

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00148a013

Reference yield:

: 97486-25-4
2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<(benzyloxy)formamido>-2-oxo-1-azetidinyl>oxy>acetate

: 97486-33-4
2-(trimethylsilyl)ethyl <<4(S)-methyl-3(S)-<<2-<(triphenylmethyl)amino>-4-thiazolyl>acetamido>-2-oxo-1-azetidinyl>oxy>acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.2N aq. HCl, H₂ / 10percent Pd/C / ethanol / 0.75 h

2: pyridine, phosphorus oxychloride / CH₂Cl₂ / 1 h

With pyridine; hydrogenchloride; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00148a013