64220-26-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]is used as an intermediate in the synthesis of various pharmaceutical compounds. One of its primary applications is in the production of (6R-trans)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (A630465), which is related to Cefdinir USP (C242670). Cefdinir is a cephalosporin antibiotic that is structurally similar to cefixime and is effective in treating infections caused by several Gram-negative and Gram-positive bacteria.
Additionally, 4-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]can be used to synthesize Cefdinir-related compounds, which may have potential applications in the development of new antibiotics or as impurities in the manufacturing process of Cefdinir. 4-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-'s role in the synthesis of pharmaceutical compounds highlights its importance in the development of new treatments for bacterial infections.

Upstream product

• 76-83-5 trityl chloride 
• 80715-43-1 ethyl 2-(2-(tritylamino)thiazol-4-yl)acetate 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 64987-16-2 (2-amino-thiazol-4-yl)-acetic acid methyl ester 
• 78287-71-5 methyl 2-tritylamino-4-thiazolylacetate 
• 29676-71-9 2-amino-4-thiazoleacetic acid 

Downstream Products

• 64223-86-5 C₂₉H₂₈N₂SO₄ 
• 945469-46-5 C₃₈H₃₈O₄N₄S 
• 945469-47-6 C₃₈H₃₈O₄N₄S 
• 945469-48-7 C₃₉H₄₀O₄N₄S 
• 945469-49-8 C₃₉H₄₀O₄N₄S 
• 115385-02-9 <2-(tritylamino)thiazol-4-yl>acetyl chloride 
• 1351823-25-0 C₄₆H₄₆N₄O₄S₂ 
• 1613316-25-8 C₄₃H₄₂N₄O₅S₂ 
• 1613316-24-7 C₄₃H₄₂N₄O₅S₂ 
• 1613316-23-6 C₄₃H₄₂N₄O₄S₃ 
• 1613316-22-5 C₄₃H₄₂N₄O₄S₃ 
• 1613316-21-4 C₄₈H₄₅N₅O₄S₂ 
• 1613316-20-3 C₄₉H₄₆N₄O₄S₂ 
• 83628-69-7 2-fluoro-1-triphenylmethyl-4-[2-(2-triphenylmethylaminothiazole-4-acetamido)ethyl]imidazole 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4′-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors

A series of 4β-(thiazol-2-yl)amino-4′-O-demethyl-4-deoxypodophyllotoxins were synthesized, and their cytotoxicities were evaluated against four human cancer cell lines (A549, HepG2, HeLa, and LOVO cells) and normal human diploid fibroblast line WI-38. Som

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazolyl-acetic or propionic acid. The compound in which C is replaced by 2-amino-4-thiazolylacetic acid inhibited FTase activity in the low nanomolar range and showed antiproliferative effect on rat aortic smooth muscle cells interfering with Ras farnesylation. On the basis of these results, 2-aminothiazole can be considered as an alternative to heterocycles, such as pyridine and imidazole, normally used in FTase inhibitors designed as non-thiol CAAX mimetics.

3-Carbamoyloxymethyl-7-(amino-4-thiazolyl-acetamido)-cephalosporanic acid derivatives

A compound of the formula STR1 wherein R is selected from the group consisting of hydrogen and a group easily removable by acid hydrolysis or hydrogenolysis, R1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms

7-Amino-thiazolyl acetamido cephalosporanic acids

Novel 7-amino-thiazolyl-acetamido-cephalosporanic acid compounds of the formula STR1 wherein R is selected from the group consisting of hydrogen and a group easily removable by acid hydrolysis or hydrogenolysis, R1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, a 5 member heterocyclic ring and a 5 member heterocyclic ring containing a ketone group and A is selected from the group consisting of hydrogen, alkali metal and equivalents of alkaline earth metals, magnesium and organic amine having antibiotic activity against gram negative and gram positive bacteria and their preparation and novel intermediates therefore. STATE OF THE ART French Pat. No. 2,255,077 of Takeda describes antibacterial cephalosporins having a different substitutent in the 3-position.