Technology Process of dimethyl 2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylate
There total 3 articles about dimethyl 2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trimethylsulfoxonium iodide;
With
sodium hydride;
In
dimethyl sulfoxide; mineral oil;
for 0.5h;
Inert atmosphere;
dimethyl 2-(3,4,5-trimethoxybenzylidene)malonate;
In
dimethyl sulfoxide; mineral oil;
at 10 - 20 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1002/ejoc.201900579
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: piperidine; acetic acid / toluene / Dean-Stark; Reflux
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 22 °C / Inert atmosphere
2.2: 22 °C / Inert atmosphere
With
piperidine; sodium hydride; acetic acid;
In
N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/ejoc.201700221
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: piperidine; acetic acid / toluene / Dean-Stark; Reflux
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 22 °C / Inert atmosphere
2.2: 22 °C / Inert atmosphere
With
piperidine; sodium hydride; acetic acid;
In
N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/ejoc.201700221
