3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile

Base Information

• Chemical Name: 3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile
• CAS No.: 1323859-11-5
• Molecular Formula: C₂₀H₁₆BrN₃S₂
• Molecular Weight: 442.403
• Mol file: 1323859-11-5.mol

Synonyms:3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile

Chemical Property of 3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile

There total 1 articles about 3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

carbon disulfide (75-15-0,12122-00-8) + 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)acetonitrile (1215114-73-0) + methyl iodide (74-88-4) → 3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile (1323859-11-5)

Guidance literature:

carbon disulfide; 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)acetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201100516

Reference yield: 62.0%

3,3-bis(methylthio)-2-(1,3-diphenyl-4-bromopyrazol-5-yl)-2-propenenitrile (1323859-11-5) → 1,3-diphenyl-5-(methylthio)-1H-thieno[3,2-c]pyrazole-6-carbonitrile

Guidance literature:

With tri-n-butylstannyl chloride; 2,2'-azobis(isobutyronitrile); sodium cyanoborohydride; In tert-butyl alcohol; at 90 ℃; for 5h; Inert atmosphere;

DOI:10.1002/ejoc.201100516

upstream raw materials:

carbon disulfide

2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)acetonitrile

methyl iodide