(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

Base Information

Chemical Name:(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine
CAS No.:858930-21-9
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

Chemical Property:

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Technology Process of (3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

There total 4 articles about (3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 742079-58-9
(3R,4R)-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

: 100-39-0
benzyl bromide

: 858930-21-9
(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm050269z

Reference yield:

: 858930-19-5
(3R,4R)-1-tert-butoxycarbonyl-4-[(tert-butyldiphenylsilyloxy)methyl]-3-methoxymethoxypyrrolidine

: 858930-21-9
(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: 88 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z

Reference yield:

: 858930-18-4
(3R,4R)-1-tert-butoxycarbonyl-4-[(tert-butyldiphenylsilyloxy)methyl]-3-hydroxypyrrolidine

: 858930-21-9
(3R,4R)-4-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / diisopropylethylamine / toluene / 3 h / 70 °C

2: 65 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: 88 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050269z