C₂₁H₂₁FN₂O₄S

Base Information

Chemical Name:C₂₁H₂₁FN₂O₄S
CAS No.:1374229-63-6
Molecular Formula:C₂₁H₂₁FN₂O₄S
Molecular Weight:416.473
Hs Code.:

C<sub>21</sub>H<sub>21</sub>FN<sub>2</sub>O<sub>4</sub>S

Synonyms:C₂₁H₂₁FN₂O₄S

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Chemical Property of C₂₁H₂₁FN₂O₄S

Chemical Property:

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Technology Process of C₂₁H₂₁FN₂O₄S

There total 6 articles about C₂₁H₂₁FN₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1374233-20-1
C₂₀H₁₈FNO₅S

: 593-51-1
methylamine hydrochloride

: 1374229-63-6
C₂₁H₂₁FN₂O₄S

Guidance literature:: C₂₀H₁₈FNO₅S; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1374229-63-6
C₂₁H₂₁FN₂O₄S

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

4.1: pyridine / dmap / dichloromethane / 2 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

6.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

6.2: 20 °C

7.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.2: 0.33 h / 20 °C

With pyridine; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 691857-07-5
ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1374229-63-6
C₂₁H₂₁FN₂O₄S

Guidance literature:: Multi-step reaction with 8 steps

1.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1 h / 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

5.1: pyridine / dmap / dichloromethane / 2 h / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

7.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

7.2: 20 °C

8.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

8.2: 0.33 h / 20 °C

With pyridine; hydrogen; boron trichloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;