(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Base Information

Chemical Name:(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol
CAS No.:328000-69-7
Molecular Formula:C₃₀H₃₄N₂O₂
Molecular Weight:454.612
Hs Code.:

Synonyms:(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

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Chemical Property of (1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

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Technology Process of (1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

There total 5 articles about (1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5162-44-7
1-bromo-4-butene

: 328000-43-7
(1S,2S,5S)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol

: 328000-69-7
(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Guidance literature:: (1S,2S,5S)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

1-bromo-4-butene; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h;
DOI:10.1055/s-2000-8719

Reference yield:

: 33162-00-4
2-Aminomethyl-4,5-diphenyl-1,3-oxazole

: 328000-69-7
(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / BF₃*OEt₂; 4 Angstroem molecular sieves / toluene / 4 h / Heating

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 72 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; 1.1: Condensation / 2.1: deprotonation / 2.2: Alkylation;
DOI:10.1055/s-2000-8719

Reference yield:

: 1845-25-6
(1S,2S,5S)-(-)-2-hydroxypinan-3-one

: 328000-69-7
(1S,2S,5S)-3-[(E)-(R)-1-(4,5-Diphenyl-oxazol-2-yl)-pent-4-enylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / BF₃*OEt₂; 4 Angstroem molecular sieves / toluene / 4 h / Heating

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 72 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene; 1.1: Condensation / 2.1: deprotonation / 2.2: Alkylation;
DOI:10.1055/s-2000-8719