C₂₄H₂₂N₄O₂

Base Information

• Chemical Name: C₂₄H₂₂N₄O₂
• CAS No.: 1407188-98-0
• Molecular Formula: C₂₄H₂₂N₄O₂
• Molecular Weight: 398.464
• Mol file: 1407188-98-0.mol

Synonyms:C₂₄H₂₂N₄O₂

Chemical Property of C₂₄H₂₂N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₂N₄O₂

There total 7 articles about C₂₄H₂₂N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

10-amino-1,2,3,4-tetrahydropyrido[2,1-a]isoindol-6(10bH)-one (1245654-44-7) + C12H8N2O → C24H22N4O2 (1407188-98-0)

Guidance literature:

In 1,4-dioxane; at 100 ℃; Inert atmosphere;

DOI:10.1021/jm3008536

Reference yield:

5-phenyl-pyridine-2-carboxylic acid (75754-04-0) → C24H22N4O2 (1407188-98-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 0.08 h / -10 °C / Inert atmosphere

1.2: 2 h / -10 °C / Inert atmosphere

2.1: sodium azide / water / 1 h / -10 °C / Inert atmosphere

3.1: toluene / 1 h / Inert atmosphere; Reflux

4.1: 1,4-dioxane / 100 °C / Inert atmosphere

With sodium azide; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; toluene; 3.1: |Curtius Rearrangement;

DOI:10.1021/jm3008536

Reference yield:

4-nitro-1H-isoindole-1,3(2H)-dione (603-62-3) → C24H22N4O2 (1407188-98-0)

Guidance literature:

Multi-step reaction with 8 steps

1: N-benzyl-trimethylammonium hydroxide / methanol; ethyl acetate / 12 h / Reflux

2: toluene-4-sulfonic acid / toluene / 12 h / Reflux; Dean-Stark

3: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.25 h / -30 °C

4: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

5: hydrogenchloride / acetone; water / 3 h / Reflux

6: palladium 10% on activated carbon; hydrogen / dichloromethane / 16 h / 20 °C

7: hydrazine hydrate; sodium / diethylene glycol / 4 h / 190 °C

8: 1,4-dioxane / 100 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetone; toluene; diethylene glycol; 1: |Michael Addition / 7: |Wolff-Kishner Reduction;

DOI:10.1021/jm3008536

upstream raw materials:

5-phenyl-pyridine-2-carboxylic acid

5-phenylpicolinoyl chloride

10-amino-1,2,3,4-tetrahydropyrido[2,1-a]isoindol-6(10bH)-one

4-nitro-1H-isoindole-1,3(2H)-dione