9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran

Base Information

• Chemical Name: 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran
• CAS No.: 1259944-67-6
• Molecular Formula: C₄₃H₃₈O₇
• Molecular Weight: 666.771
• Mol file: 1259944-67-6.mol

Synonyms:9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran

Chemical Property of 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran

There total 3 articles about 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-bromo-4-methoxy-benzene (104-92-7) + ethyl 9-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran-5-carboxylate → 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran (1259944-67-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -70 - 20 ℃; Inert atmosphere;

DOI:10.1039/c0cc02986f

Reference yield:

ethyl 4-hydroxy-6-methoxynaphthalene-2-carboxylate (538343-03-2) → 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran (1259944-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum oxide / toluene / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane; cyclohexane / 2 h / -70 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

With aluminum oxide; n-butyllithium; In tetrahydrofuran; hexane; cyclohexane; toluene;

DOI:10.1016/j.dyepig.2011.07.004

Reference yield:

1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (101597-25-5) → 9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran (1259944-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum oxide / toluene / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane; cyclohexane / 2 h / -70 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

With aluminum oxide; n-butyllithium; In tetrahydrofuran; hexane; cyclohexane; toluene;

DOI:10.1016/j.dyepig.2011.07.004

upstream raw materials:

1-bromo-4-methoxy-benzene

1,1-bis(4-methoxyphenyl)-2-propyn-1-ol

ethyl 4-hydroxy-6-methoxynaphthalene-2-carboxylate

Downstream raw materials:

C₄₃H₃₆O₆

3,7-dimethoxy-11,11,12-tris(4-methoxyphenyl)-11Hbenzo[5,6]pentaleno[1,2-b]naphthalene-5-one