2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester
• CAS No.: 538343-03-2
• Molecular Formula: C14H14O4
• Molecular Weight: 246.25900
• DSSTox Substance ID: DTXSID301227969
• Nikkaji Number: J1.999.779K
• Mol file: 538343-03-2.mol

Synonyms:538343-03-2;2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester;2-Naphthalenecarboxylic acid,4-hydroxy-6-methoxy-,ethyl ester;DTXSID301227969;4-Hydroxy-6-methoxy-2-naphthoic acid ethyl ester;Ethyl 4-hydroxy-6-methoxy-2-naphthalenecarboxylate

Chemical Property of 2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester

Chemical Property:

• Vapor Pressure: 3.32E-08mmHg at 25°C
• Boiling Point: 435.9oC at 760 mmHg
• Flash Point: 167oC
• PSA: 55.76000
• Density: 1.228g/cm3
• LogP: 2.73070
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 246.08920892
• Heavy Atom Count: 18
• Complexity: 292

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC(=C2C=C(C=CC2=C1)OC)O

Technology Process of 2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester

There total 3 articles about 2-Naphthalenecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 4-acetoxy-6-methoxynaphthalene-2-carboxylate (151502-73-7) → ethyl 4-hydroxy-6-methoxynaphthalene-2-carboxylate (538343-03-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 1.5h;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → ethyl 4-hydroxy-6-methoxynaphthalene-2-carboxylate (538343-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethoxide / ethanol / 4 h / Heating

2: sodium acetate / 3 h / Heating

3: 75 percent / potassium carbonate / methanol / 1.5 h / 20 °C

With sodium ethanolate; sodium acetate; potassium carbonate; In methanol; ethanol; 1: Stobbe condensation;

Reference yield:

(E)-4-(4-methoxyphenyl)-3-carbethoxyethylbut-3-enoic acid (151502-67-9) → ethyl 4-hydroxy-6-methoxynaphthalene-2-carboxylate (538343-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / 3 h / Heating

2: 75 percent / potassium carbonate / methanol / 1.5 h / 20 °C

With sodium acetate; potassium carbonate; In methanol;

upstream raw materials:

ethyl 4-acetoxy-6-methoxynaphthalene-2-carboxylate

4-methoxy-benzaldehyde

(E)-4-(4-methoxyphenyl)-3-carbethoxyethylbut-3-enoic acid

Downstream raw materials:

ethyl 2,2-bis(4-dimethylaminophenyl)-9-methoxy-2H-naphtho[1,2-b]pyran-5-carboxylate

ethyl 2-(4-dimethylaminophenyl)-9-methoxy-2-(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran-5-carboxylate

2-(dimethylamino)-5-[4-(dimethylamino)phenyl]-10-methoxy-6,6-bis(4-methoxyphenyl)benzo[5,6]pentaleno[1,2-b]naphthalen-12(6H)-one

9-methoxy-5-[1,1-bis(4-methoxyphenyl)-1-hydroxymethyl]-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran