3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

Base Information

Chemical Name:3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate
CAS No.:852158-13-5
Molecular Formula:C₂₂H₃₄N₂O₄S₂Si
Molecular Weight:482.74
Hs Code.:

Synonyms:3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

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Chemical Property of 3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

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Technology Process of 3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

There total 7 articles about 3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 852158-11-3
4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methyl-3-nitro-pyridin-2-yl-methanesulfonate

: 852158-13-5
3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 0.5h; under 760 Torr;
DOI:10.1016/j.tetlet.2005.02.128

Reference yield:

: 4521-31-7
o-hydroxymethyl thiophenol

: 852158-13-5
3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / dimethylformamide / 6 h / 20 °C

2: 78 percent / K₂CO₃ / CH₂Cl₂ / 10 h / 20 °C

3: 95 percent / H₂ / Pd/C / ethanol / 0.5 h / 760 Torr

With 1H-imidazole; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.02.128

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 852158-13-5
3-amino-4-[2-(tert-butyldimethylsilanoxymethyl)phenylsulfanyl]-5-ethyl-6-methylpyridin-2-yl-methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / dimethylformamide / 6 h / 20 °C

2: 78 percent / K₂CO₃ / CH₂Cl₂ / 10 h / 20 °C

3: 95 percent / H₂ / Pd/C / ethanol / 0.5 h / 760 Torr

With 1H-imidazole; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.02.128