Technology Process of (Z)-(4R,6R,8R)-17,19-Bis-methoxymethoxy-4-methyl-12-phenylsulfanyl-3,7-dioxa-tricyclo[13.4.0.06,8]nonadeca-1(19),9,15,17-tetraene-2,13-dione
There total 11 articles about (Z)-(4R,6R,8R)-17,19-Bis-methoxymethoxy-4-methyl-12-phenylsulfanyl-3,7-dioxa-tricyclo[13.4.0.06,8]nonadeca-1(19),9,15,17-tetraene-2,13-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
toluene;
at 120 ℃;
for 0.166667h;
DOI:10.1002/anie.200454108
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / P(mClPh)3; DIAD / toluene / 3 h / 23 °C
2: 91 percent / DIPEA; TBAI / dimethylformamide / 3 h / 80 °C
3: 81 percent / LDA / tetrahydrofuran / -78 °C
4: 94 percent / Grubbs catalyst / toluene / 0.17 h / 120 °C
With
Grubbs catalyst first generation; di-isopropyl azodicarboxylate; tri(m-chlorophenyl)-phosphine; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1: Mitsunobu reaction;
DOI:10.1002/anie.200454108
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / K2CO3 / dimethylformamide / 3 h / 23 °C
2: 82 percent / LDA; HMPA / tetrahydrofuran / 3 h / -78 - -23 °C
3: 81 percent / LDA / tetrahydrofuran / -78 °C
4: 94 percent / Grubbs catalyst / toluene / 0.17 h / 120 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; Grubbs catalyst first generation; potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.200454108
