2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

Base Information

Chemical Name:2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol
CAS No.:1361218-43-0
Molecular Formula:C₁₇H₁₈BrF₃N₂O₃S₂
Molecular Weight:499.373
Hs Code.:

Synonyms:2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

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Chemical Property of 2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

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Technology Process of 2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

There total 4 articles about 2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16629-19-9
thiophene-2-sulfonyl chloride

: 1361218-42-9
tert-butyl 4-(2-bromo-4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

: 1361218-43-0
2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

Guidance literature:: tert-butyl 4-(2-bromo-4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate; With hydrogenchloride; In 1,4-dioxane; ethyl acetate; for 0.5h; Reflux;

thiophene-2-sulfonyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1361218-43-0
2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 2 h / 100 °C / sealed tube

3.1: bromine / ethanol / 0.25 h

4.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0.5 h / Reflux

4.2: 0.25 h / 0 °C

With hydrogenchloride; n-butyllithium; bromine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In 1,4-dioxane; hexanes; diethyl ether; ethanol; ethyl acetate; toluene;

Reference yield:

: 122243-28-1
2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol

: 1361218-43-0
2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 2 h / 100 °C / sealed tube

2.1: bromine / ethanol / 0.25 h

3.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0.5 h / Reflux

3.2: 0.25 h / 0 °C

With hydrogenchloride; bromine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In 1,4-dioxane; ethanol; ethyl acetate; toluene;