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122243-28-1

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122243-28-1 Usage

General Description

2-(4-bromophenyl)-1,1,1-trifluoropropan-2-ol is a chemical compound with a molecular formula of C9H9BrF3O. It is a fluorinated alcohol with a trifluoromethyl group and a bromine substituent attached to a benzene ring. 2-(4-broMophenyl)-1,1,1-trifluoropropan-2-ol is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in organic chemistry research as a building block for the production of various compounds. Due to its unique structure and reactivity, 2-(4-bromophenyl)-1,1,1-trifluoropropan-2-ol has applications in a wide range of chemical and industrial processes.

Check Digit Verification of cas no

The CAS Registry Mumber 122243-28-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,2,4 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 122243-28:
(8*1)+(7*2)+(6*2)+(5*2)+(4*4)+(3*3)+(2*2)+(1*8)=81
81 % 10 = 1
So 122243-28-1 is a valid CAS Registry Number.

122243-28-1Downstream Products

122243-28-1Relevant articles and documents

CRYSTAL POLYMORPHISM OF KCNQ2-5 CHANNEL ACTIVATOR

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Paragraph 0107, (2019/05/18)

Crystal polymorphism may exist in a crystalline compound. In the case where crystal polymorphism exists, depending on the crystal form, solubility, dissolution rate, stability against heat, light, humidity, etc. or the like is different. Accordingly, in t

KCNQ2-5 CHANNEL ACTIVATOR

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Paragraph 0386-0388, (2017/08/26)

The present invention relates to a compound represented by the general formula (I) (wherein the definition of each group has the same meaning as described in the specification). The compound is useful as preventive and/or therapeutic agent for KCNQ2-5 cha

Small molecule disruptors of the Glucokinase-Glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

Ashton, Kate S.,Andrews, Kristin L.,Bryan, Marion C.,Chen, Jie,Chen, Kui,Chen, Michelle,Chmait, Samer,Croghan, Michael,Cupples, Rod,Fotsch, Christopher,Helmering, Joan,Jordan, Steve R.,Kurzeja, Robert J. M.,Michelsen, Klaus,Pennington, Lewis D.,Poon, Steve F.,Sivits, Glenn,Van, Gwyneth,Vonderfecht, Steve L.,Wahl, Robert C.,Zhang, Jiandong,Lloyd, David J.,Hale, Clarence,St. Jean, David J.

, p. 309 - 324 (2014/02/14)

Small molecule activators of glucokinase have shown robust efficacy in both preclinical models and humans. However, overactivation of glucokinase (GK) can cause excessive glucose turnover, leading to hypoglycemia. To circumvent this adverse side effect, we chose to modulate GK activity by targeting the endogenous inhibitor of GK, glucokinase regulatory protein (GKRP). Disrupting the GK-GKRP complex results in an increase in the amount of unbound cytosolic GK without altering the inherent kinetics of the enzyme. Herein we report the identification of compounds that efficiently disrupt the GK-GKRP interaction via a previously unknown binding pocket. Using a structure-based approach, the potency of the initial hit was improved to provide 25 (AMG-1694). When dosed in ZDF rats, 25 showed both a robust pharmacodynamic effect as well as a statistically significant reduction in glucose. Additionally, hypoglycemia was not observed in either the hyperglycemic or normal rats.

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