4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate

Base Information

• Chemical Name: 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate
• CAS No.: 1382748-92-6
• Molecular Formula: C₁₆H₁₀ClFN₂O₄
• Molecular Weight: 348.718
• Mol file: 1382748-92-6.mol

Synonyms:4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate

Chemical Property of 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate

There total 4 articles about 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) + 4-chloro-2-oxo-1,3-benzoxazine-6-yl acetate (1382748-91-5) → 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate (1382748-92-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1080/00397911.2011.573169

Reference yield:

2,4-dioxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate (1382748-90-4) → 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate (1382748-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride / 0.33 h / 165 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1080/00397911.2011.573169

Reference yield:

Methyl 2,5-dihydroxybenzoate (2150-46-1) → 4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate (1382748-92-6)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium hydroxide / 13 h / 50 °C

2: 1 h / 122 °C

3: pyridine / 3 h / 20 - 100 °C / Inert atmosphere

4: phosphorus pentachloride / 0.33 h / 165 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With pyridine; ammonium hydroxide; phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1080/00397911.2011.573169

upstream raw materials:

2,4-dioxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

3-chloro-4-fluorophenylamine

4-chloro-2-oxo-1,3-benzoxazine-6-yl acetate

Methyl 2,5-dihydroxybenzoate

Downstream raw materials:

4-(3-chloro-4-fluorophenylimino)-6-hydroxy-3-methyl-3,4-dihydro-1,3-benzoxazine-2-one

C₁₄H₈ClFN₂O₃

4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate