4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

Base Information

Chemical Name:4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate
CAS No.:1382748-96-0
Molecular Formula:C₁₇H₁₂ClFN₂O₄
Molecular Weight:362.745
Hs Code.:

Synonyms:4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

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Chemical Property of 4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

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Technology Process of 4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

There total 4 articles about 4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.9%

: 1382748-92-6
4-(3-chloro-4-fluorophenylamino)-2-oxo-1,3-benzoxazine-6-yl acetate

: 74-88-4
methyl iodide

: 1382748-96-0
4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3h;
DOI:10.1002/jhet.2463

Reference yield:

: 1382748-90-4
2,4-dioxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

: 1382748-96-0
4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus pentachloride / 0.33 h / 165 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 40 °C

3.2: 8 h / 70 °C / Inert atmosphere

With phosphorus pentachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00397911.2011.573169

Reference yield:

: 52405-73-9
gentisamide

: 1382748-96-0
4-(3-chloro-4-fluorophenylimino)-3-methyl-2-oxo-3,4-dihydro-1,3-benzoxazine-6-yl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1 h / 122 °C

2.1: pyridine / 3 h / 20 - 100 °C / Inert atmosphere

3.1: phosphorus pentachloride / 0.33 h / 165 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 40 °C

5.2: 8 h / 70 °C / Inert atmosphere

With pyridine; phosphorus pentachloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00397911.2011.573169