rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

Base Information

Chemical Name:rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one
CAS No.:124988-85-8
Molecular Formula:C₁₆H₁₉NO₄
Molecular Weight:289.331
Hs Code.:

Synonyms:rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

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Chemical Property of rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

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Technology Process of rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

There total 7 articles about rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7681-84-7
tetrahydrofuran-2-carbaldehyde

: 124988-85-8
rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: KH

2: DIBAH / CH₂Cl₂ / -78 °C

3: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4: silver nitrate / acetonitrile / 24 h

5: DMSO, anhydrous sodium acetate / 1 h / Ambient temperature

6: diethyl ether; tetrahydrofuran / Ambient temperature

7: 77 percent / benzene / 12 h / Heating

With pyridine; sodium acetate; potassium hydride; diisobutylaluminium hydride; silver nitrate; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo00293a040

Reference yield:

: 122592-49-8
(R,S)-(Z)-3-(2-Tetrahydrofuryl)propenoic acid methyl ester

: 124988-85-8
rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: DIBAH / CH₂Cl₂ / -78 °C

2: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3: silver nitrate / acetonitrile / 24 h

4: DMSO, anhydrous sodium acetate / 1 h / Ambient temperature

5: diethyl ether; tetrahydrofuran / Ambient temperature

6: 77 percent / benzene / 12 h / Heating

With pyridine; sodium acetate; diisobutylaluminium hydride; silver nitrate; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo00293a040

Reference yield:

: 124919-03-5
Bromo-acetic acid (Z)-3-(tetrahydro-furan-2-yl)-allyl ester

: 124988-85-8
rac-3-(2-Tetrahydrofuryl)tetrahydro-1-(phenylmethyl)-1H,6H-furo<3,4-c>isoxazol-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: silver nitrate / acetonitrile / 24 h

2: DMSO, anhydrous sodium acetate / 1 h / Ambient temperature

3: diethyl ether; tetrahydrofuran / Ambient temperature

4: 77 percent / benzene / 12 h / Heating

With sodium acetate; silver nitrate; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; acetonitrile; benzene;
DOI:10.1021/jo00293a040