4-(4-Azidophenyl)butyric acid

Base Information

• Chemical Name: 4-(4-Azidophenyl)butyric acid
• CAS No.: 103489-33-4
• Molecular Formula: C10H11 N3 O2
• Molecular Weight: 205.21
• DSSTox Substance ID: DTXSID90544302
• Nikkaji Number: J2.904.271C
• Wikidata: Q82421380
• Mol file: 103489-33-4.mol

Synonyms:4-(4-AZIDOPHENYL)BUTYRIC ACID;103489-33-4;4-(4-azidophenyl)butanoic acid;4-(4-azidophenyl)butylic acid;SCHEMBL14720056;DTXSID90544302;MFCD00798800;AKOS030255364

Chemical Property of 4-(4-Azidophenyl)butyric acid

Chemical Property:

• PSA: 87.05000
• LogP: 2.48846
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 205.085126602
• Heavy Atom Count: 15
• Complexity: 253

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Azidophenyl)butyricAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCCC(=O)O)N=[N+]=[N-]

Technology Process of 4-(4-Azidophenyl)butyric acid

There total 2 articles about 4-(4-Azidophenyl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-(4-aminophenyl)butyric Acid (15118-60-2) → γ-(4-azidophenyl)butyric acid (103489-33-4)

Guidance literature:

4-(4-aminophenyl)butyric Acid; With sulfuric acid; sodium nitrite; at 0 ℃; for 0.75h;

With sodium azide; at 0 ℃; for 0.666667h;

DOI:10.1016/S0960-894X(99)00511-9

Reference yield:

4-(4-nitrophenyl)butanoic acid (5600-62-4) → γ-(4-azidophenyl)butyric acid (103489-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / H₂ / 10 percent Pd/C / methanol / 6 h / 20 °C

2.1: aq. NaNO₂; aq. H₂SO₄ / 0.75 h / 0 °C

2.2: 71 percent / aq. NaN₃ / 0.67 h / 0 °C

With sulfuric acid; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol; 1.1: Reduction / 2.1: Diazotization / 2.2: Substitution;

DOI:10.1016/S0960-894X(99)00511-9

Reference yield: 92.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + γ-(4-azidophenyl)butyric acid (103489-33-4) → 4-azidophenyl butyric acid 4-nitrophenyl ester (253325-35-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0960-894X(99)00511-9

upstream raw materials:

4-(4-aminophenyl)butyric Acid

4-(4-nitrophenyl)butanoic acid

Downstream raw materials:

4-azidophenyl butyric acid 4-nitrophenyl ester

4-(4-(4-(3-(3-(4-(1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-butyric acid

4-(4-(4-(4-(3-(4-(1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-butyl)-(1,2,3)triazol-1-yl)-phenyl)-butyric acid

4-(4-(4-(3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-butyric acid