4-azidophenyl butyric acid 4-nitrophenyl ester

Base Information

• Chemical Name: 4-azidophenyl butyric acid 4-nitrophenyl ester
• CAS No.: 253325-35-8
• Molecular Formula: C₁₆H₁₄N₄O₄
• Molecular Weight: 326.312
• Mol file: 253325-35-8.mol

Synonyms:4-azidophenyl butyric acid 4-nitrophenyl ester

Chemical Property of 4-azidophenyl butyric acid 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-azidophenyl butyric acid 4-nitrophenyl ester

There total 3 articles about 4-azidophenyl butyric acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + γ-(4-azidophenyl)butyric acid (103489-33-4) → 4-azidophenyl butyric acid 4-nitrophenyl ester (253325-35-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0960-894X(99)00511-9

Reference yield:

4-(4-nitrophenyl)butanoic acid (5600-62-4) → 4-azidophenyl butyric acid 4-nitrophenyl ester (253325-35-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 85 percent / H₂ / 10 percent Pd/C / methanol / 6 h / 20 °C

2.1: aq. NaNO₂; aq. H₂SO₄ / 0.75 h / 0 °C

2.2: 71 percent / aq. NaN₃ / 0.67 h / 0 °C

3.1: 92 percent / DCC / CH₂Cl₂ / 1 h / 20 °C

With sulfuric acid; hydrogen; dicyclohexyl-carbodiimide; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane; 1.1: Reduction / 2.1: Diazotization / 2.2: Substitution / 3.1: Condensation;

DOI:10.1016/S0960-894X(99)00511-9

Reference yield:

4-(4-aminophenyl)butyric Acid (15118-60-2) → 4-azidophenyl butyric acid 4-nitrophenyl ester (253325-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaNO₂; aq. H₂SO₄ / 0.75 h / 0 °C

1.2: 71 percent / aq. NaN₃ / 0.67 h / 0 °C

2.1: 92 percent / DCC / CH₂Cl₂ / 1 h / 20 °C

With sulfuric acid; dicyclohexyl-carbodiimide; sodium nitrite; In dichloromethane; 1.1: Diazotization / 1.2: Substitution / 2.1: Condensation;

DOI:10.1016/S0960-894X(99)00511-9

upstream raw materials:

4-nitro-phenol

γ-(4-azidophenyl)butyric acid

4-(4-nitrophenyl)butanoic acid

4-(4-aminophenyl)butyric Acid