2-phenethylthiomethylpyridine

Base Information

• Chemical Name: 2-phenethylthiomethylpyridine
• CAS No.: 58086-71-8
• Molecular Formula: C₁₃H₁₃NS
• Molecular Weight: 215.319
• Mol file: 58086-71-8.mol

Synonyms:2-phenethylthiomethylpyridine

Chemical Property of 2-phenethylthiomethylpyridine

Chemical Property:

Purity/Quality:

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Technology Process of 2-phenethylthiomethylpyridine

There total 32 articles about 2-phenethylthiomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester (114050-31-6) → 2-phenethylthiomethylpyridine (58086-71-8)

Guidance literature:

With 2-(trimethylsilyloxy)acrylic acid ethyl ester; In dichloromethane; at 0 - 5 ℃; Irradiation;

DOI:10.1016/0040-4020(94)01054-4

Reference yield: 80.0%

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester (114050-31-6) + 3-pyridyl isocyanide (85526-38-1) → 2-phenethylthiomethylpyridine (58086-71-8) + 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester (119541-41-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -15 ℃; for 0.166667h; Product distribution; Irradiation; examination of temperature, irradiation time, further N-hydroxy-2-thiopyridone esters;

DOI:10.1016/S0040-4020(01)85980-9

Reference yield: 77.0%

2-bromo-pyridine (109-04-6) + 2-phenylethyl chloride (622-24-2) → 2-phenethylthiomethylpyridine (58086-71-8)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Sodium thiosulfate pentahydrate; caesium carbonate; In ethylene glycol; dimethyl sulfoxide; at 120 ℃; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1021/ol500112y

upstream raw materials:

1-hydroxy-2(1H)-pyridinethione

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester

crotononitrile

N-(Isobutyroyloxy)pyridine-2-thione

Downstream raw materials:

2-(2-phenylethylsulphinyl)pyridine