3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester

Base Information

• Chemical Name: 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester
• CAS No.: 119541-41-2
• Molecular Formula: C₁₉H₁₇N₃S
• Molecular Weight: 319.43
• Mol file: 119541-41-2.mol

Synonyms:3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester

Chemical Property of 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester

There total 1 articles about 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester (114050-31-6) + 3-pyridyl isocyanide (85526-38-1) → 2-phenethylthiomethylpyridine (58086-71-8) + 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester (119541-41-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -15 ℃; for 0.166667h; Product distribution; Irradiation; examination of temperature, irradiation time, further N-hydroxy-2-thiopyridone esters;

DOI:10.1016/S0040-4020(01)85980-9

Reference yield: 90.0%

3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester (119541-41-2) → 3-phenyl-N-(pyridin-3-yl)propanamide (119520-49-9)

Guidance literature:

With water; In 1,4-dioxane; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85980-9

Reference yield:

3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester (119541-41-2) → 3-Phenylpropionic acid (501-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / water / dioxane / 12 h / Ambient temperature

2: 1.) hexamethyldisilazane, 1.6 M n-BuLi, 2.) CS₂, 3.) PhSeO₂H / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, rt, 3.) THF, rt, 5 h

With carbon disulfide; n-butyllithium; benzeneseleninic acid; water; 1,1,1,3,3,3-hexamethyl-disilazane; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)85980-9

upstream raw materials:

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester

3-pyridyl isocyanide

Downstream raw materials:

3-phenyl-N-(pyridin-3-yl)propanamide

3-phenylthiopropionic acid

3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester

3-phenylpropanoic dithioperoxyanhydride