(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Base Information

Chemical Name:(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide
CAS No.:1095005-78-9
Molecular Formula:C₂₆H₃₀N₄O₄
Molecular Weight:462.549
Hs Code.:

Synonyms:(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

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Chemical Property of (R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

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Technology Process of (R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

There total 11 articles about (R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₉BrN₄O₄

: 1095005-78-9
(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; at 100 ℃; for 2h; Mixrowave irradiation;

Reference yield:

: (R)-2-(2-(1-aminopropyl)phenoxy)ethanol

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 765-30-0
Cyclopropylamine

: 1095005-78-9
(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: (R)-2-(2-(1-aminopropyl)phenoxy)ethanol; methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 96h; Inert atmosphere;

With triethylamine; for 17h;

Cyclopropylamine; Further stages;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095005-78-9
(R)-N-cyclopropyl-3-(3-(1-(2-(2-hydroxyethoxy)phenyl)propylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: triethylamine / tetrahydrofuran / 120 h / 20 °C

3: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.25 h

4: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 100 °C / Mixrowave irradiation

With ammonium formate; triethylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; 1,2-dichloro-benzene;