1H-INDOLE-2-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-AMIDE

Base Information

Chemical Name:1H-INDOLE-2-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-AMIDE
CAS No.:103420-82-2
Molecular Formula:C25H20 N4 O2
Molecular Weight:408.459
Hs Code.:
Mol file:103420-82-2.mol

Synonyms:1H-Indole-2-carboxamide,N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, (R)-;1H-1,4-Benzodiazepine, 1H-indole-2-carboxamide deriv.; (R)-L 364718

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-INDOLE-2-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-AMIDE

Chemical Property:

PSA：77.56000
LogP:3.62930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-INDOLE-2-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-AMIDE

There total 10 articles about 1H-INDOLE-2-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL)-AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 58881-45-1
Indole-2-carbonyl chloride

: 103343-65-3
(3R)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 103420-82-2
1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm00120a002

Reference yield:

: 108895-98-3
benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

: 103420-82-2
1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / HBr / acetic acid / 1.) 70 deg C, 20 min, 2.) 80 deg C, 20 min

2: Et₃N / acetonitrile / Heating

3: 93 percent / NaH / dimethylformamide / 1.) 0 - 5 deg C, 1.5 h, 2.) 1.5 h

4: 93 percent / HBr / CH₂Cl₂ / 0.5 h / 0 - 5 °C

5: EDC, HOBT, DIEA / CH₂Cl₂ / Ambient temperature

With hydrogen bromide; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00108a044

Reference yield:

: 108895-97-2
2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone

: 103420-82-2
1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: NH₄OAc / acetic acid / Ambient temperature

2: 88 percent / HBr / acetic acid / 1.) 70 deg C, 20 min, 2.) 80 deg C, 20 min

3: Et₃N / acetonitrile / Heating

4: 93 percent / NaH / dimethylformamide / 1.) 0 - 5 deg C, 1.5 h, 2.) 1.5 h

5: 93 percent / HBr / CH₂Cl₂ / 0.5 h / 0 - 5 °C

6: EDC, HOBT, DIEA / CH₂Cl₂ / Ambient temperature

With ammonium acetate; hydrogen bromide; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00108a044