(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Base Information

Chemical Name:(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid
CAS No.:1423218-39-6
Molecular Formula:C₂₂H₂₄BrNO₃
Molecular Weight:430.341
Hs Code.:

Synonyms:(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Suppliers and Price of (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

There total 6 articles about (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1423218-38-5
C₂₄H₂₈BrNO₃

: 1423218-39-6
(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 40 ℃; for 3h;
DOI:10.1016/j.tetlet.2013.01.003

Reference yield:

: 496-15-1
1-indoline

: 1423218-39-6
(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 100 °C

2: trichlorophosphate / 4 h / 25 - 35 °C

3: bromine / dichloromethane / 2.5 h / 0 °C

4: dichloromethane; toluene / 16 h / Reflux

5: sodium hydroxide / methanol; water / 3 h / 40 °C

With bromine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: |Vilsmeier-Haack Formylation / 4: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.01.003

Reference yield:

: 26420-79-1
1-chloro-3-benzyloxypropane

: 1423218-39-6
(E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 100 °C

2: trichlorophosphate / 4 h / 25 - 35 °C

3: bromine / dichloromethane / 2.5 h / 0 °C

4: dichloromethane; toluene / 16 h / Reflux

5: sodium hydroxide / methanol; water / 3 h / 40 °C

With bromine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: |Vilsmeier-Haack Formylation / 4: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.01.003