tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate
CAS No.:1423218-40-9
Molecular Formula:C₃₇H₄₄F₃N₃O₅
Molecular Weight:667.769
Hs Code.:

Synonyms:tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

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Chemical Property of tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

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Technology Process of tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

There total 38 articles about tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 459868-77-0
2,3-dihydro-1-[3-(phenylmethoxy)propyl]-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

: 1423218-40-9
tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2013.01.003

Reference yield: 65.0%

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 160969-20-0
tert-butyl [(2R)-1-(7-cyanoindolin-5-yl)propan-2-yl]-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}carbamate

: 1423218-40-9
tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

Guidance literature:: tert-butyl [(2R)-1-(7-cyanoindolin-5-yl)propan-2-yl]-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}carbamate; With sodium hydride; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

1-[(3-bromopropoxy)methyl]-benzene; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tet.2013.01.061

Reference yield: 45.0%

: 1-(3-(benzyloxy)propyl)-5-iodoindoline-7-carbonitrile

: 1,3-dioxoisoindolin-2-yl (R)-3-((tert-butoxycarbonyl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)butanoate

: 1423218-40-9
tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

Guidance literature:: With nickel(II) iodide; 4-methoxypyridine-2-carboxamidine hydrochloride; lithium bromide; zinc; In N,N-dimethyl acetamide; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2021.153290