1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ )

Base Information

• Chemical Name: 1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ )
• CAS No.: 103412-68-6
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 103412-68-6.mol

Synonyms:1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ )

Chemical Property of 1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ )

Chemical Property:

• PSA: 72.63000
• LogP: 2.95860

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ )

There total 12 articles about 1H-1-BENZAZEPINE 1- ACETIC ACID, 3-AMINO-2,3,4,5-TETRAHYDRO-2-OXO PHENYL METHYL ESTER (+ ) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetic acid benzyl ester (368426-46-4) → benzyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-acetate (183508-58-9,103412-68-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (86499-35-6) + Benzyl bromoacetate (5437-45-6) → 3-amino-1-benzyloxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (86499-26-5,103412-68-6)

Guidance literature:

With tetrabutylammomium bromide; In N-methyl-acetamide;

Reference yield:

3-azido-1-benzyloxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one → 3-amino-1-benzyloxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (86499-26-5,103412-68-6)

Guidance literature:

aluminum nickel; In hydrogenchloride; ethanol; water;

upstream raw materials:

(3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetic acid benzyl ester

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

1-tetralone oxime

3,4-dihydronaphthalene-1(2H)-one

Downstream raw materials:

benazepril hydrochloride