2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

Base Information

Chemical Name:2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid
CAS No.:1420468-79-6
Molecular Formula:C₂₁H₂₁F₃N₄O₃
Molecular Weight:434.418
Hs Code.:

Synonyms:2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

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Chemical Property of 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

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Technology Process of 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

There total 9 articles about 2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 201230-82-2
carbon monoxide

: 1420468-78-5
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidine

: 1420468-79-6
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

Guidance literature:: With methanol; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 22h;
DOI:10.1021/ml300330m

Reference yield: 53.0%

: 1420468-49-0
3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-ol

: 1420468-78-5
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidine

: 1420468-79-6
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

Guidance literature:: With sodium hydroxide; palladium diacetate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 261952-16-3
1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene

: 1420468-79-6
2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: N,N-dimethyl-formamide / 2.5 h / 0 - 40 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

3: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

4: N,N-diethylaniline; trichlorophosphate / 3.25 h / 0 - 80 °C / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran / 3 h / 50 °C

6: ethanol / 3 h / 145 °C / Microwave irradiation

7: N,N-diethylaniline; trichlorophosphate / 0.58 h / 0 - 80 °C / Inert atmosphere

8: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; methanol; triethylamine / N,N-dimethyl-formamide / 22 h / 70 °C

With methanol; 1,1'-bis-(diphenylphosphino)ferrocene; sodium methylate; palladium diacetate; hydrazine hydrate; triethylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300330m