maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide

Base Information

• Chemical Name: maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide
• CAS No.: 1399843-22-1
• Molecular Formula: C₄₀H₄₅N₅O₄
• Molecular Weight: 659.828

Synonyms:maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide

Chemical Property of maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide

Chemical Property:

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Technology Process of maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide

There total 3 articles about maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(5R,9R,13R,17R)-5,9-dimethyl-19-(1-methylethyl)-15-oxa-14,16-dioxopentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]heptadec-18-ene-5-carbonyl chloride (53109-98-1) + 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (152460-10-1) → maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide (1399843-22-1)

Guidance literature:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; With triethylamine; In tetrahydrofuran; at 60 - 65 ℃; for 0.5h;

(5R,9R,13R,17R)-5,9-dimethyl-19-(1-methylethyl)-15-oxa-14,16-dioxopentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]heptadec-18-ene-5-carbonyl chloride; In tetrahydrofuran; at 60 - 65 ℃;

DOI:10.1134/S1070428012080143

Reference yield:

maleopimaric acid (510-39-4) → maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide (1399843-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.5 h / 60 - 65 °C

2.2: 60 - 65 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1134/S1070428012080143

Reference yield:

C30H35N3O5 + 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (152460-10-1) → maleopimaric acid N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide (1399843-22-1)

Guidance literature:

With dmap; at 18 - 20 ℃; for 36h;

DOI:10.1134/S1070428012080143

upstream raw materials:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

maleopimaric acid

(5R,9R,13R,17R)-5,9-dimethyl-19-(1-methylethyl)-15-oxa-14,16-dioxopentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]heptadec-18-ene-5-carbonyl chloride

Downstream raw materials:

C₄₀H₄₅N₅O₄*CH₄O₃S

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