(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Base Information

Chemical Name:(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester
CAS No.:56151-97-4
Molecular Formula:C₂₁H₃₁NO₅
Molecular Weight:377.481
Hs Code.:

Synonyms:(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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Chemical Property of (3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Chemical Property:

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Technology Process of (3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

There total 8 articles about (3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75821-62-4,109741-44-8,109741-45-9,109785-73-1,109785-74-2
(4S)-1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

: 56151-97-4
(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

: 56151-98-5
(3S,4S)-(+)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In perchloric acid; ethanol; for 20h; under 3040 Torr;
DOI:10.1016/S0040-4020(01)83119-7

Reference yield:

: 75821-60-2
(3R,4S)-(+)-1-(3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic acid ethyl ester

: 56151-97-4
(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaBH₄ / ethanol / 4 h / 0 - 5 °C

2: 1.)(ethylenedinitrilo)tetraacetic acid disodium salt dihydrate and Hg(OAc)2; 2.) anhyd. K₂CO₃ / 1.) 1percent aq. AcOH, reflux, 1.5h; 2.) EtOH, RT, 5h

3: H₂ / 10percent Pd-C / ethanol; aq. HClO₄ / 20 h / 3040 Torr

With sodium tetrahydroborate; mercury(II) diacetate; hydrogen; edetate disodium; potassium carbonate; palladium on activated charcoal; In perchloric acid; ethanol;
DOI:10.1016/S0040-4020(01)83119-7

Reference yield:

: 56246-53-8
(+)-ethyl cincholoiponate

: 56151-97-4
(3R,4S)-(-)-1-(3,4-dimethoxyphenethyl)-3-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / benzene / 4 h / Heating

2: 90 percent / NaBH₄ / ethanol / 4 h / 0 - 5 °C

3: 1.)(ethylenedinitrilo)tetraacetic acid disodium salt dihydrate and Hg(OAc)2; 2.) anhyd. K₂CO₃ / 1.) 1percent aq. AcOH, reflux, 1.5h; 2.) EtOH, RT, 5h

4: H₂ / 10percent Pd-C / ethanol; aq. HClO₄ / 20 h / 3040 Torr

With sodium tetrahydroborate; mercury(II) diacetate; hydrogen; edetate disodium; potassium carbonate; palladium on activated charcoal; In perchloric acid; ethanol; benzene;
DOI:10.1016/S0040-4020(01)83119-7