tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Base Information

Chemical Name:tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate
CAS No.:95779-48-9
Molecular Formula:C₂₇H₃₄N₂O₅S
Molecular Weight:498.643
Hs Code.:

Synonyms:tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Suppliers and Price of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

There total 11 articles about tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 3(R)-amino-4-oxo-2,3,4,5-tetrahydrol-1,5-benzothiazepine-5-acetate

: 60-29-7,927820-24-4
diethyl ether

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 95779-67-2
tert-butyl (R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 95779-47-8
tert-butyl 3(R)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 95779-48-9
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: With oxalic acid; sodium cyanoborohydride; acetic acid; molecular sieve; In ethanol; water; ethyl acetate; Petroleum ether;

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 95779-48-9
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

3: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

4: 74 percent / NaH / dimethylformamide / 0.33 h

5: 71 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

6: 31 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

With 4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 88-74-4
2-nitro-aniline

: 95779-48-9
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / NaNO₂ / Ambient temperature

2: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

4: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

5: 74 percent / NaH / dimethylformamide / 0.33 h

6: 71 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

7: 31 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

With 4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128