4-(bromomethyl)-1-chloro-2-methoxybenzene

Base Information

• Chemical Name: 4-(bromomethyl)-1-chloro-2-methoxybenzene
• CAS No.: 103347-14-4
• Molecular Formula: C8H8 Br Cl O
• Molecular Weight: 235.508
• Hs Code.: 2909309090
• Mol file: 103347-14-4.mol

Synonyms:3-Methoxy-4-chlorobenzylbromide; 4-Bromomethyl-1-chloro-2-methoxybenzene; 4-Chloro-3-methoxybenzylbromide

Chemical Property of 4-(bromomethyl)-1-chloro-2-methoxybenzene

Chemical Property:

• Boiling Point: 115 °C(Press: 0.4 Torr)
• PSA: 9.23000
• Density: 1.520±0.06 g/cm3(Predicted)
• LogP: 3.24350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

98%min ^*data from raw suppliers

4-(Bromomethyl)-1-chloro-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Bromomethyl)-1-chloro-2-methoxybenzene is an intermediate in the synthesis of 5-(3-((1H-1,2,4-Triazol-1-yl)methyl)-3-hydroxy-4,4-dimethylpentyl)-2-chlorophenol (T767575), which is a tebuconazole impurity. Tebuconazole (T013000) is an ergosterol biosynthesis inhibitor. Fungicide.

Technology Process of 4-(bromomethyl)-1-chloro-2-methoxybenzene

There total 11 articles about 4-(bromomethyl)-1-chloro-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-methylanisole (73909-16-7) → 4-(bromomethyl)-1-chloro-2-methoxybenzene (103347-14-4)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 1h; Reflux;

Reference yield:

(4-chloro-3-methoxyphenyl)methan-1-ol (13726-17-5) → 4-(bromomethyl)-1-chloro-2-methoxybenzene (103347-14-4)

Guidance literature:

With phosphorus tribromide; Yield given;

DOI:10.1016/S0040-4039(00)85221-1

Reference yield:

2,2'-azolbis(4-methoxy-2,4-diaethylvaleronitrile) + 2-chloro-5-methylanisole (73909-16-7) → 4-(bromomethyl)-1-chloro-2-methoxybenzene (103347-14-4)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane;

upstream raw materials:

(4-chloro-3-methoxyphenyl)methan-1-ol

2-chloro-5-methylanisole

4-chloro-3-methoxybenzaldehyde

3-hydroxy-4-chlorobenzaldehyde

Downstream raw materials:

2-(4-chloro-3-methoxyphenyl)acetonitrile

2-{[4-chloro-3-(methyloxy)phenyl]methyl}-1H-isoindole-1,3(2H)-dione

(4-chloro-3-methoxyphenyl)methanamine

2-[1-(tert-butoxycarbonyl)-4-piperidinylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide

Refernces

• 1、 -. "SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES". Paragraph 1532; 1533. . Retrieved 2020/03/26.
• 2、 -. "CHEMICAL COMPOUNDS". Page/Page column 93-94. . Retrieved 2012/02/02.