(2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

Base Information

Chemical Name:(2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol
CAS No.:1229345-59-8
Molecular Formula:C₃₂H₅₄O₄Si₂
Molecular Weight:558.949
Hs Code.:

Synonyms:(2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

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Chemical Property of (2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

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Technology Process of (2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

There total 1 articles about (2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1229345-53-2
((2S,3S)-3-((2S,3S,4S)-5-[(1,1-dimethylethyl)diphenylsilyloxy]-4-methyl-3-(triethylsilyloxy)pentan-2-yl)oxiran-2-yl)methanol

: 917-54-4
methyllithium

: 1229345-59-8
(2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

Guidance literature:: methyllithium; With copper(l) iodide; In tetrahydrofuran; diethyl ether; at 0 ℃; Inert atmosphere;

((2S,3S)-3-((2S,3S,4S)-5-[(1,1-dimethylethyl)diphenylsilyloxy]-4-methyl-3-(triethylsilyloxy)pentan-2-yl)oxiran-2-yl)methanol; In tetrahydrofuran; diethyl ether; at -15 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Inert atmosphere;
DOI:10.1021/ol100985n

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 1229345-59-8
(2R,3R,4S,5S,6S)-7-[(1,1-dimethylethyl)diphenylsilyloxy]-2,4,6-trimethyl-5-(triethylsilyloxy)heptane-1,3-diol

: 5-methyl-2-(4-methoxyphenyl)-4-[(2S,3S,4S)-4-methyl-3-triethylsilyloxy-5-[(1,1-dimethylethyl)diphenylsilyloxy]pentan-2-yl]-1,3-dioxane

: 1229345-60-1
5-methyl-2-(4-methoxyphenyl)-4-[(2S,3S,4S)-4-methyl-3-triethylsilyloxy-5-[(1,1-dimethylethyl)diphenylsilyloxy]pentan-2-yl]-1,3-dioxane

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene; for 2h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol100985n