2,2-dimethyl-3-phenyl-3-butenoic acid

Base Information

• Chemical Name: 2,2-dimethyl-3-phenyl-3-butenoic acid
• CAS No.: 13686-41-4
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• Mol file: 13686-41-4.mol

Synonyms:2,2-dimethyl-3-phenyl-3-butenoic acid

Chemical Property of 2,2-dimethyl-3-phenyl-3-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-3-phenyl-3-butenoic acid

There total 5 articles about 2,2-dimethyl-3-phenyl-3-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl 2,2-dimethyl-3-phenyl-3-butenoate (72012-45-4) → 2,2-dimethyl-3-phenyl-3-butenoic acid (13686-41-4)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; for 6h; Reflux; Inert atmosphere;

DOI:10.1021/ol5022433

Reference yield:

tert-butyl 2,2-dimethyl-3-phenylbut-3-enoate → 2,2-dimethyl-3-phenyl-3-butenoic acid (13686-41-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate (25491-42-3) → 2,2-dimethyl-3-phenyl-3-butenoic acid (13686-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 1 h / 70 °C / Inert atmosphere

1.2: 20 h / 55 °C / Inert atmosphere

2.1: sodium hydroxide / diethyl ether; water / 6 h / Reflux; Inert atmosphere

With sodium hydride; sodium hydroxide; In diethyl ether; water; dimethyl sulfoxide; mineral oil;

DOI:10.1021/ol5022433

upstream raw materials:

ethyl 2,2-dimethyl-3-phenyl-3-butenoate

ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate

Downstream raw materials:

α,β,β-trimethylstyrene

2-methyl-3-phenylbut-3-en-2-yl acetate

carbon dioxide

3-methyl-2-phenyl-1-butene