1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

Base Information

• Chemical Name: 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine
• CAS No.: 39667-62-4
• Molecular Formula: C₁₆H₁₀BrClN₄
• Molecular Weight: 373.639
• Mol file: 39667-62-4.mol

Synonyms:1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

Chemical Property of 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

There total 6 articles about 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

estazolam (29975-16-4) → 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine (39667-62-4)

Guidance literature:

With pyridine; bromine; In chloroform; for 0.5h; Heating;

DOI:10.1135/cccc19832395

Reference yield: 52.8%

N-[4-(2-benzoyl-4-chloro-phenyl)-5-bromo-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide (62893-27-0) → 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine (39667-62-4)

Guidance literature:

With hydrazine hydrate; In ethanol; 1) room temp., 2.5 h; 2) 63 deg C_.;

DOI:10.1002/jhet.5570170331

Reference yield:

1,3-Dioxo-2-isoindolineacetic Acid, <methylene>hydrazine (59010-35-4) → 1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine (39667-62-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / trifluoroacetic acid / toluene / 1.5 h / 100 - 110 °C

2: 77.6 percent / N-bromosuccinimide / benzene / 7 h / Heating

3: 52.8 percent / hydrazin hydrate / ethanol / 1) room temp., 2.5 h; 2) 63 deg C_.

With N-Bromosuccinimide; hydrazine hydrate; trifluoroacetic acid; In ethanol; toluene; benzene;

DOI:10.1002/jhet.5570170331

upstream raw materials:

estazolam

N-[4-(2-benzoyl-4-chloro-phenyl)-5-bromo-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

1,3-Dioxo-2-isoindolineacetic Acid, <methylene>hydrazine

N-[4-(2-benzoyl-4-chloro-phenyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

Downstream raw materials:

8-chloro-1-morpholin-4-yl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

8-chloro-1-<4-(2-methoxyethyl)piperazino>-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

8-chloro-2,4-dihydro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one

8-chloro-2-(3-dimethylamino-propyl)-6-phenyl-2,4-dihydro-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-one