FMOC-ILE-CL

Base Information

• Chemical Name: FMOC-ILE-CL
• CAS No.: 103321-51-3
• Molecular Formula: C21H22 Cl N O3
• Molecular Weight: 371.864
• Mol file: 103321-51-3.mol

Synonyms:Carbamicacid, [(1S,2S)-1-(chlorocarbonyl)-2-methylbutyl]-, 9H-fluoren-9-ylmethyl ester(9CI); Carbamic acid, [1-(chlorocarbonyl)-2-methylbutyl]-,9H-fluoren-9-ylmethyl ester, [S-(R*,R*)]-;N-(9-Fluorenylmethoxycarbonyl)isoleucyl chloride

Chemical Property of FMOC-ILE-CL

Chemical Property:

• Melting Point: 101-103 °C
• Boiling Point: 518.8±33.0 °C(Predicted)
• PKA: 10.36±0.46(Predicted)
• PSA: 55.40000
• Density: 1.213±0.06 g/cm3(Predicted)
• LogP: 5.09610

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-Ile-Cl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-ILE-CL

There total 1 articles about FMOC-ILE-CL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Fmoc-Ile-OH (71989-23-6,251316-98-0) → ((1S,2S)-1-Chlorocarbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (103321-51-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 2h; Sonication;

DOI:10.1002/chem.201704307

Reference yield: 91.0%

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) + ((1S,2S)-1-Chlorocarbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (103321-51-3) → [(1S,2S)-1-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethylcarbamoyl)-2-methyl-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:

With sodium carbonate; In chloroform; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200300563

Reference yield: 91.0%

((1S,2S)-1-Chlorocarbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (103321-51-3) + 2-carbomethoxyaniline (134-20-3) → Fmoc-L-Ile-Ant-OMe (125511-95-7)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; for 0.166667h;

DOI:10.1248/cpb.37.930

upstream raw materials:

Fmoc-Ile-OH

Downstream raw materials:

Fmoc-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Fmoc-L-Ile-D-(N^δ-Cbz)Piz-L-Pip-D-(N-Me)Phe-L-Pro-OCH2Ph

Fmoc-L-Ile-D-Pip-L-Pip-D-(N-Me)Phe-OCH₂Ph

Fmoc-L-Ile-D-Pip-L-Pip-D-(N-allyl)Phe-L-Pro-OCH₂Ph

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 103321-51-3 FMOC-ILE-CL

Send

Send

Metric Ton KG G Pound L ML

Send

Send