α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

Base Information

Chemical Name:α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile
CAS No.:68284-66-2
Molecular Formula:C₂₃H₃₆FN₃
Molecular Weight:373.557
Hs Code.:

Synonyms:α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

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Chemical Property of α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

Chemical Property:

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Technology Process of α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

There total 4 articles about α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 326-62-5
2-fluorophenyl acetonitrile

: 68284-66-2
α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaNH₂ / toluene / 0.5 h / 80 - 85 °C

2: NaNH₂ / 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min

With sodium amide; In toluene;
DOI:10.1021/jm00184a008

Reference yield:

: 96-79-7
(2-chloroethyl)-diisopropylamine

: 68284-66-2
α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaNH₂ / toluene / 0.5 h / 80 - 85 °C

2: NaNH₂ / 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min

With sodium amide; In toluene;
DOI:10.1021/jm00184a008

Reference yield:

: 1932-03-2
2-(piperidin-4-yl)ethyl chloride

: 68284-65-1
4-Diisopropylamino-2-(2-fluoro-phenyl)-butyronitrile

: 68284-66-2
α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile

Guidance literature:: With sodium amide; Yield given. Multistep reaction; 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min;
DOI:10.1021/jm00184a008