tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate
CAS No.:916483-47-1
Molecular Formula:C₃₁H₃₅F₂N₇O₅
Molecular Weight:623.66
Hs Code.:

tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

There total 12 articles about tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 916483-50-6
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

: 59378-81-3,69610-40-8,83435-58-9
1-(tert-butoxycarbonyl)prolin-2R-ol

: 916483-47-1
tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 916483-52-8
2-(4-bromo-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide

: 916483-47-1
tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

1.2: 4 h / 90 °C

2.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

3.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

4.1: isopropyl alcohol / 0.75 h / 90 °C

5.1: pyridine; pyridine hydrochloride / 42 h / 120 °C

6.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

With pyridine; hydrogenchloride; di-tert-butyl-diazodicarboxylate; pyridine hydrochloride; sodium hydrogencarbonate; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 916483-51-7
2-chloro-N-(2,3-difluorophenyl)acetamide

: 916483-47-1
tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 18 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

2.2: 4 h / 90 °C

3.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

5.1: isopropyl alcohol / 0.75 h / 90 °C

6.1: pyridine; pyridine hydrochloride / 42 h / 120 °C

7.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

With pyridine; hydrogenchloride; di-tert-butyl-diazodicarboxylate; pyridine hydrochloride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ISOPROPYLAMIDE; water; ethyl acetate; isopropyl alcohol;