N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

Base Information

Chemical Name:N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide
CAS No.:916483-50-6
Molecular Formula:C₂₁H₁₈F₂N₆O₃
Molecular Weight:440.409
Hs Code.:

Synonyms:N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

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Chemical Property of N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

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Technology Process of N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

There total 11 articles about N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 916483-48-2
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride

: 916483-50-6
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

Guidance literature:: With pyridine; pyridine hydrochloride; at 120 ℃; for 42h;

Reference yield:

: 916483-52-8
2-(4-bromo-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide

: 916483-50-6
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

1.2: 4 h / 90 °C

2.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

3.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

4.1: isopropyl alcohol / 0.75 h / 90 °C

5.1: pyridine; pyridine hydrochloride / 42 h / 120 °C

With pyridine; hydrogenchloride; pyridine hydrochloride; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 916483-51-7
2-chloro-N-(2,3-difluorophenyl)acetamide

: 916483-50-6
N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 18 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.08 h

2.2: 4 h / 90 °C

3.1: hydrogenchloride / water; ethyl acetate / 1.02 h / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

5.1: isopropyl alcohol / 0.75 h / 90 °C

6.1: pyridine; pyridine hydrochloride / 42 h / 120 °C

With pyridine; hydrogenchloride; pyridine hydrochloride; sodium hydrogencarbonate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ISOPROPYLAMIDE; water; ethyl acetate; isopropyl alcohol;